Comprehensive Bone Marrow Evaluation:

• Includes Morphologic examination, Flow Cytometry, Cytogenetics, Immunohistochemistry, Molecular and FISH analysis as determined by a Hematopathologist.

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Flow Cytometry:

• Comprehensive Analysis
• ZAP70 Panel
• PNH Panel
• T-Lymphocytes Subsets

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Cytogenetics:

• Analysis of bone marrow and peripheral blood for constitutional and acquired abnormalities

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Fluorescent in situ Hybridization (FISH)

 

Indication	Probe Name	Target Point of Analysis
AML	CBFB-BA	inv(16)
	MLL-BA	11q23
	PML/RARA	t(15;17)
	AML1/ETO	21q22/8q22
ALL	TEL/AML1	t(12;21)
	MLL-BA	11q23
	BCR/ABL	t(9;22)
B-CLL	ATM/P53	17p13.1/11q22.3
	D13S319/13q34/CEP12	13q14.3/13q34/12CEN
CML	BCR/ABL	t(9;22)
MDS	CSFIR/D5S23:D5S721	5q31;5p15.2
	D7S486/CEP7	7q31/7CEN
	CEP 8	8cen
	D20S108	20q12
Myeloma	BCL-1 (CCND1/IGH)	t(11;14)
	D13S25	13q14.3
	CEP 4	centromere 4
	IGH/FGFR3	t(4;14)
	CEP 6	6 cen
	CEP 17	17cen
	CEP 9	9cen
NHL / Lymphoma	IGH	14q32
	BCL-1 (CCND1/IGH)	t(11;14)
	CEP 3	3cen
	API2/MALT1	t(11;18)
	MALT1	18q21
	MYC/IGH	8q24
	BCL-2	t(14;18)
	BCL-6	3q27
	MYB	6q22-23
	MYC/IGH	8q24
	ALK	2p23
Her-2/Neu	Her-2/Neu
Miscellaneous	CEP 11	11cen
	CEP 3	3cen
	CEP 7	7cen
	XY	XY

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Molecular (PCR)

• BCR/ABL
• BCR/ABL (Quantitative)
• BCL1
• FLT3
• B-CELL Gene Rearrangement
• PML/RARA
• JAK2
• BCL2
• IgVh Mutation Analysis
• T-CELL Gene Rearrangement
• C-KIT Mutation
• FIPILI-PDGFRA

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UroVysion

• UroVysion (Urinary Tract Specimen by FISH)

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HER2/neu

• HER2/neu (By FISH)

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Coagulation Factors Genetic Testing

• Factor II
• Factor V Leiden
• MTHFR

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Warfarin Genetic Testing

• Warfarin Sensitivity Genetic Test

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HPV

• HPV with Genotyping (By PCR)

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Cystic Fibrosis Genetic Testing